Yulia Golub

 

CAPPLab

Child and Adolescent Psychopathology

Yulia Golub, Dr. rer. nat.

Professional experience

since 10/2017

Principal Investigator and head consultant of the addiction unit, Department

of Child and Adolescent Psychiatry of the Medical Faculty Carl Gustav Carus

at the TU Dresden and a head of the in-patient department for addiction treatment

at the Department for Child and Adolescent Psychiatry and Psychotherapy,

State Hospital Arnsdorf, Germany

 

2016

Specialist for Child and Adolescent Psychiatry and Psychotherapy

 

2012-2017

Research Group Leader, University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Child and Adolescent Mental Health, Erlangen, Germany

Education & Training

2014-2016

Resident and research associate, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Hospital, Frankfurt am Main, Germany

 

2013-2014

Resident, Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Heidelberg University

 

2011-2013

Curriculum Children and adolescents cognitive behavioral therapy, Center for Integrative Psychotherapy, Munich

 

2009-2013

Resident and research associate, University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Child and Adolescent Mental Health, Erlangen

 

2006-2010

PhD Thesis (Dr. rer. nat.): “Associative and non-associative fear in Posttraumatic Stress Disorder”. Max Planck Institute of Psychiatry, Munich

 

2003-2005

Graduate Master Program in Neural & Behavioural Sciences, International Max Planck Research School, University of Tuebingen, Germany

 

1997-2003

Medical School, Samara State University, Russia.

Research interests

  • Addiction research: Development of the effective treatment strategies, biomarkers of addiction-vulnerability and treatment response
  • Molecular and epigenetic mechanisms involved in the effects of prenatal toxins/stress/trauma exposure
  • Stress and neuropeptide systems in child and adolescent anxiety disorders

Honors and Awards

2017-present

Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) University Grant ELAN-Fonds for the Project „ Effects of prenatal trauma on maternal hormone balance, placenta function and expression of HPA-axis related genes in fetal brain and placenta“

 

2015-2016

Staedtler-Foundation (grant participant): „The effects of prenatal alcohol exposure in primary- school children“

 

2015

Travel Grant for participation in the World Congress of Biological Psychiatry.

 

2012-2014

Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) University Grant ELAN-Fonds for the Project „Establishing a mouse model of prenatal traumatic experience.”

 

2010

Poster Award at the congress „Biological Child and Adolescence psychiatry“ in Ulm for the Poster Sauerhoefer E, Pamplona FA, Moll GH, Dawirs RR, von Hoersten S, Wotjak CT, Golub Y. „Associative and non-associative fear in the mouse model of Posttraumatic Stress disorder (PTSD)“

 

2003-2005

DAAD scholarship for Master’s studies in Graduate School of Neural & Behavioural Sciences, University of Tuebingen

Selected Publications

Frey S, Eichler A, Stonawski V, Kriebel J, Wahl S, Gallati S, Goecke TW, Fasching PA, Beckmann MW, Kratz O, Moll GH, Heinrich H, Kornhuber J*, Golub Y*: Prenatal alcohol exposure is associated with adverse cognitive effects and distinct whole-genome DNA methylation patterns in primary school children. Submitted Translational Psychiatry. (submitted Clinical Epiigenetics)

 

Stonawski V, Frey S, Golub Y, Moll GH, Heinrich H, Eichler A: [Epigenetic modifications in children associated with maternal emotional stress during pregnancy]. Z Kinder Jugendpsychiatr Psychother, Mar 3:1-13, 2017.

 

Golub Y, Canneva F, Funke R, Frey S, Distler J, von Hörsten S, Freitag CM, Kratz O, Moll GH, Solati J. Effects of in-utero environment and maternal behaviour on neuroendocrine and behavioural alterations in a mouse model of prenatal trauma. Dev Neurobiol, 76(11):1254-1265, 2016.

 

Funke R, Eichler A, Distler J, Golub Y, Kratz O, Moll, GH: Stress system dysregulation in pediatric generalized anxiety disorder associated with comorbid depression. Stress and Health, in press, 2016.

 

Canneva F, Golub Y, Distler J, Dobner J, Meyer S, von Hörsten S. DPP4-deficient congenic rats display blunted stress, improved fear extinction and increased central NPY. Psychoneuroendocrinology. 53: 195-206, 2015.

 

Solati J, Kleehaupt E, Kratz O, Moll GH, Golub Y: Inverse effects of lipopolysaccharides on anxiety in pregnant mice and their offspring. Physiol Behav. 139:369-74, 2015.

 

Schöpf I, Easton AC, Solati J, Golub Y, Kornhuber J, Giese KP, Müller CP: αCaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice. Neurosci Lett, 30; 591:65-8, 2015.

 

Solati J, Hajikhani R, Golub Y: Activation of GABAA receptors in the medial prefrontal cortex produces an anxiolytic-like response. Acta Neuropsychiatr, 25(4):221-6, 2013.

 

Easton AC, Lucchesi W, Lourdusamy A, Lenz B, Solati J, Golub Y, Lewczuk P, Fernandes C, Desrivieres S, Dawirs RR, Moll GH, Kornhuber J, Frank J, Hoffmann P, Soyka M, Kiefer F; GESGA Consortium, Schumann G, Peter Giese K, Müller CP, Treutlein J, Cichon S, Ridinger M, Mattheisen P, Herms S, Wodarz N, Zill P, Maier W, Mössner R, Gaebel W, Dahmen N, Scherbaum N, Schmäl C, Steffens M, Lucae S, Ising M, Müller-Myhsok B, Nöthen MM, Mann K, Rietschel M: αCaMKII autophosphorylation controls the establishment of alcohol drinking behavior. Neuropsychopharmacology, 38(9):1636-47, 2013.

 

Easton AC, Lourdusamy A, Havranek M, Mizuno K, Solati J, Golub Y, Clarke TK, Vallada H, Laranjeira R, Desrivières S, Moll GH, Mössner R, Kornhuber J, Schumann G, Giese KP, Fernandes C, Quednow BB, Müller CP: αCaMKII controls the establishment of cocaine's reinforcing effects in mice and humans. Transl Psychiatry, 7;4:e457, 2014.

 

Solati J, Hajikhani R, Golub Y: Activation of GABAA receptors in the medial prefrontal cortex produces an anxiolytic-like response. Acta Neuropsychiatr, 25(4):221-6, 2013.

 

Sauerhoefer E, Pamplona FA, Bedenk B, Moll GH, Dawirs RR, von Hörsten S, Wotjak CT, Golub Y: Generalized contextual fear and avoidance after fear incubation depend on associative rather than non-associative memory components. Behavioural Brain Research, 30; 233(2):483-493, 2012.

 

Herrmann L, Ionescu I, Henes K, Golub Y, Wang N, Buell DR, Holsboer F, Wotjak CT, Schmidt U: Neuropeptide S (NPS) and Fluoxetine Counteract Trauma Stress-Induced Long-Term Reduction of Hippocampal Synaptic Protein Expression. PLoSONE 7(8); e42603, 2012.

 

Golub Y, Kaltwasser SF, Mauch CP, Herrmann L, Schmidt U, Holsboer F, Czisch M, Wotjak CT. Reduced hippocampus volume in the mouse model of Posttraumatic Stress Disorder. Journal of Psychiatric Research, May;45(5):650-9, 2011.

 

Dahlhoff M, Siegmund A, Golub Y, Wolf E, Holsboer F, Wotjak CT: AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms. Neuroscience, 169(3):1216-26, 2010.

 

Golub Y, Mauch CP, Dahlhoff M, Wotjak CT: Consequences of extinction training on associative and non-associative fear in a mouse model of Posttraumatic Stress Disorder (PTSD). Behav Brain Res, 28;205(2):544-9, 2009.

 

Golub Y, Berg D, Calne D, Pfeiffer R, Uitti R, Stoessl J, Wszolek Z, Farrer M, Mueller J, Gasser T, Fuchs J: Genetic factors influencing age at onset in LRRK2 linked Parkinson disease. Parkinsonism Relat Disord, 15(7):539-41, 2009.

 

Fuchs J, Tichopad A, Golub Y, Munz M, Schweitzer K, Wolf B, Berg D, Mueller J and Gasser T: a-synuclein expression in blood and brain depends on genetic variability. FASEB J, 22(5):1327-34, 2008.

Current Responsibilities

  • Addiction Study

Contact information

Medical Faculty Carl Gustav Carus

Technische Universität Dresden

Department of Child and Adolescent Psychiatry and Psychotherapy

Fetscherstraße 74, 01307 Dresden

 

Email: Yulia.Golub@uniklinikum-dresden.de